77. Lingchao Kong, Rahi M. Reja, Yuhan Lyu, and Jianmin Gao*, “Tuning the Residence Time of Lysine-Targeting Reversible Covalent Warheads,” in preparation for submission in July 2023.
76. Yuhan Lyu, Fan Yang, Bharathi Sundaresh, Federico Rosconi, Tim van Opijnen, and Jianmin Gao*, “Covalent Inhibition of a Host-Pathogen Protein-Protein Interaction Curbs the Virulence of Streptococcus pneumoniae,” in preparation for submission in June 2023.
75. Mengmeng Zheng and Jianmin Gao*, “Phage Display of Two Distinct Warheads to Inhibit Challenging Proteins,” under review.
74. Rahi M. Reja, Brittney Chau and Jianmin Gao*, “Diazaborine Mediated Bicyclization of Native Peptides with Inducible Reversibility,” Org. Lett., 2023, https://pubs.acs.org/doi/full/10.1021/acs.orglett.3c01496.
73. Brittney Chau, Kristi Liivak, and Jianmin Gao*, “Construction of Nonnatural Cysteine-Crosslinked Phage Libraries,” Methods in Molecular Biology – Bacteriophages, 2023, edited by Professor Ebenzer Tumban, in press.
72. Fa-Jie Chen,# Nicole Pinnette,# Fan Yang, and Jianmin Gao*, “A Cysteine-Directed Proximity-Driven Crosslinking Method for Native Peptide Bicyclization,” Angew. Chem. Int. Ed., 2023, 10.1002/anie.202306813. #co-first authors
71. Fa-Jie Chen and Jianmin Gao*, “Fast Cysteine Bioconjugation Chemistry,” Chem. Eur. J., 2022, 28, e202201843. https://doi-org.proxy.bc.edu/10.1002/chem.202201843
69. Mengmeng Zheng, Fredrik Haeffner and Jianmin Gao*, “N-Terminal cysteine mediated backbone-side chain cyclization for chemically enhanced phage display,” Chem. Sci., 2022, 13, 8349-54. https://doi-org.proxy.bc.edu/10.1039/D2SC03241D
68. Dmitry Leshchiner, Emily Rudmann, Bharathi Sundaresh, Luisa Nieto, Andy Nishimoto, Federico Rosconi, Bimal Jana, Noemi Garcia, Kaiching Li, Jianmin Gao, Jason Rosch and Tim van Opijnen, “A Genome-Wide Atlas of Antibiotic Susceptibility: Targets and Pathways to Tolerance,” Nat Commun, 2022 doi/10.1038/s41467-022-30967-4
67. Fa-Jie Chen#, Mengmeng Zheng#, Vincent Nobile, Jianmin Gao*, “Fast and Cysteine-Specific Modification of Peptides, Proteins and Bacteriophage Using Chlorooximes,” Chem. Eur. J., 2022, 28, e202200058
66. Rahi M. Reja, Wenjian Wang, Yuhan Lyu, Fredrik Haeffner, and Jianmin Gao*, “Lysine-Targeting Reversible Covalent Inhibitors with Long Residence Time,” J. Am. Chem. Soc., 2022, 144, 1152-7. https://doi.org/10.1021/jacs.1c12702.
65. Jianmin Gao* and Vincent Nobile, “Chemistry Perspectives of Reversible Covalent Drugs,” Ann. Rep. Med. Chem., 2021, 56, 75-94. https://doi.org/10.1016/bs.armc.2020.10.004
64. Michael Kelly,ǂ Samantha Cambray,ǂ Kelly A. McCarthy, Wenjian Wang, Juan Ortiz-Marquez, Tim van Opijnen, and Jianmin Gao*, “Peptide Probes of Colistin Resistance Discovered via Chemically Enhanced Phage Display,” ACS Infect. Dis., 2020, 6, 2410-18 ǂdenotes equal contribution authors.
63. Kaicheng Li,ǂ Wenjian Wang,ǂ and Jianmin Gao*, “Fast and Stable N-Terminal Cysteine Modification via Thiazolidino Boronate Mediated Acyl Transfer,” Angew. Chem. Int. Ed. 2020, 59, 14246-50. doi.org/10.1002/anie.202000837. ǂdenotes equal contribution authors.
62. Narendra Kumar†, Wenjian Wang†, Juan C. Ortiz-Marquez †, Matthew Catalano, Mason Gray, Nadia Biglari, Kitadai Hikari, Xi Ling, Jianmin Gao*, Tim van Opijnen*, Kenneth S Burch*, “Dielectrophoresis assisted rapid, selective and single cell detection of antibiotic resistant bacteria with G-FETs,” Biosens. Bioelecton. 2020, 156:112123. doi:10.1016/j.bios.2020.112123. A preprint of this paper can be found in bioRxiv, https://www.biorxiv.org/content/10.1101/842187v1.
61. Wenjian Wang and Jianmin Gao*, “N, S-Double Labeling of N-Terminal Cysteines via an Alternative Conjugation Pathway with 2-Cyanobenzothiazole,” J. Org. Chem., 2020, 85, 1756-63.
60. Tolulope A. Aweda, F. Zumrut B. Muftuler, Adriana V. F. Massicano, Dhruval Gadhia, Stacy Queern, Kelly A. McCarthy, Anupam Bandyopadhyay, Jianmin Gao, and Suzanne E. Lapi*, “Radiolabeled Cationic Peptides for Targeted Imaging of Infection,” Contrast Media & Molecular Imaging, 2019, in press.
59. Kaicheng Li,ǂ Michael A. Kelly,ǂ and Jianmin Gao*, “Biocompatible conjugation of Tris base to 2-acetyl and 2-formyl phenylboronic acid,” Org. Biomol. Chem., 2019, 17, 5908-12. ǂdenotes equal contribution authors
58. Sam Cambray and Jianmin Gao*, “Versatile Conjugation Chemistries of ortho-Boronyl Aryl Ketones and Aldehydes,” Acc. Chem. Res., 2018, 51, 2198-206.
57. Kelly A. McCarthy, Michael A. Kelly, Kaicheng Li, Samantha Cambray, Azade Hosseini, Tim van Opijnen, and Jianmin Gao*, “Phage display of dynamic covalent binding motifs enables facile development of targeted antibiotics,” J. Am. Chem. Soc., 2018, 140, 6137-45.
56. Yang Liu, Ling Yuan, Changwei Pan, Jianmin Gao, Wenxiu Zhou, Qingyu Gao*, “Photo-Induced Oscillations and Pulse Waves in the Hydrogen Peroxide-Sulfite-Ferrocyanide Reaction," J. Phys. Chem. Part A, 2018, 122, 1175-84.
55. Kaicheng Li,ǂ Chelsea Weidman,ǂ and Jianmin Gao*, “Dynamic formation of imidazolidino boronate enables design of cysteine-responsive peptides,” Org. Lett., 2018, 20, 20-3. ǂdenotes equal contribution authors.
54. Samantha Cambray, Anupam Bandyopadhyay, and Jianmin Gao*, “Fluorogenic Diazaborine Formation of Semicarbazide with Designed Coumarin Derivatives,” Chem. Comm., 2017, 53, 12532-5.
53. Jianmin Gao*, “Cation-pi lights up 'Halo',” Biochemistry, 2017, 56, 5221-2.
52. Azade S. Hosseini*, Christopher J. Pace, Adam A. Esposito and Jianmin Gao*, “Non-additive stabilization by halogenated amino acids reveals protein plasticity on a sub-angstrom scale,” Protein Science, 2017, 26, 2051-8.
51. Kaicheng Li and Jianmin Gao*, “Iminoboronate-mediated peptide cyclization with lysine homologues,” SynLett, 2017, 28, 1913-6.
50. Azade Hosseini, Wenjian Wang, Fredrik Haeffner,* and Jianmin Gao*, “Metal-assisted Folding of Prolinomycin Allows Facile Design of Functional Peptides,” ChemBioChem, 2017, DOI: 10.1002/cbic.201600667.
49. Anupam Bandyopadhyay,# Samantha Cambray,# and Jianmin Gao*, “Fast diazaborine formation of semicarbazide enables facile labeling of bacterial pathogens,” J. Am. Chem. Soc., 2017, DOI: 10.1021/jacs.6b11115. (# denotes co-first authors.)
48. John W. Patrick, Breanna Zerfas, Jianmin Gao and David H. Russell*, “Rapid capillary mixing experiments for the analysis of hydrophobic membrane complexes directly from aqueous lipid bilayer solutions,” Analyst, 2017, DOI: 10.1039/C6AN02290A.
47. Yan-Jiun Lee, M. J. Schmidt, Jeffery M. Tharp, Annemarie Weber, Amber L. Koenig, Hong Zheng, Jianmin Gao, Marcey L. Waters, Daniel Summerer* and Wenshe R. Liu*, “Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader,” Chem Commun., 2016, 52, 12606-9.
46. Jianmin Gao* and Azade S. Hosseini, “Current understanding of π–π interactions and the applications in protein design,” Chapter 21 – “Non-covalent Interactions in the Synthesis and Design of New Compounds” by the Wiley Publishing Group, 2016, ISBN: 978-1-119-10989-1.
45. Anupam Bandyopadhyay and Jianmin Gao*, “Targeting Biomolecules with Reversible Covalent Chemistry,” Curr. Opion. Chem. Biol., 2016, 34, 110-6.
44. Anupam Bandyopadhyay, Samantha Cambray, and Jianmin Gao*, “Fast and Selective Labeling of N-terminal Cysteines via Boronic Aid-Accelerated Conjugation,” Chem. Sci., 2016, 7, 4589-93.
43. Breanna Zerfas, Yechaan Joo, and Jianmin Gao*, “Gramicidin A mutants with antibiotic activity against both gram-positive and gram-negative bacteria,” ChemMedChem, 2016, 11, 629-36.
42. Anupam Bandyopadhyay and Jianmin Gao*, “Iminoboronate-Based Peptide Cyclization That Responds to pH, Oxidation, and Small Molecule Modulators,” J. Am. Chem. Soc. 2016, 138, 2098-101.
41. Anupam Bandyopadhyay and Jianmin Gao*, “Iminoboronate Formation Leads to Fast and Reversible Conjugation Chemistry of a-Nucleophiles at Neutral pH,” Chem. Eur. J., 2015, 21, 14748-52.
40. Breanna Zerfas and Jianmin Gao*, “Recent Advances in Peptide Immunomodulators,” Curr. Top. Med. Chem., 2015, 16, 187-205.
39. Tao He, Anne Gershenson, Stephen J. Eyles, Yan-Jiun Lee, Wenshe R. Liu, Jiangyun Wang, Jianmin Gao, and Mary F. Roberts*, “Fluorinated aromatic amino acids distinguish cation-π interactions from membrane insertion,” J. Biol. Chem., 2015, 290, 19334-42.
38. Anupam Bandyopadhyay, Kelly A. McCarthy, Michael A. Kelly and Jianmin Gao*, “Targeting Bacteria via Iminoboronate Chemistry of Amine-Presenting Lipids,” Nat. Commun., 2015, DOI: 10.1038/ncomms7561.
37. Anupam Bandyopadhyay and Jianmin Gao*, “Cancer-Targeting Peptides,” eBook Chapter (Page 71-84) – “Advances in the discovery and development of peptide therapeutics” by the Future Science Group, 2015, ISBN: 978-1-910419-01-4.
36. Ya-Juan Wang*, Bamidele O. Tayo, Anupam Bandyopadhyay, Heming Wang, Tao Feng, Nora Franceschini, Hua Tang, Jianmin Gao, Yun Ju Sung, Robert C. Elston, Scott M. Williams, Richard S. Cooper, Ting-Wei Mu, Xiaofeng Zhu* "The Association of the Vanin-1 N131S Variant with Blood Pressure is Mediated by Endoplasmic-Reticulum-Associated Degradation and Loss of Function, " PLOS Genetics 2014, doi:10.1371/journal.pgen.1004641.
35. Azade Hosseini, Hong Zheng and Jianmin Gao*, "Understanding Lipid Recognition by Protein-Mimicking Cyclic Peptides, " Tetrahedron 2014, 70, 7632-8.
34. Fang Wang, Luoheng Qin, Patrick Wong and Jianmin Gao*, “Effects of Lysine Methylation on Gramicidin A Folding in Lipid Membranes,” Biopolymers: Peptide Science 2013, 100, 656-61.
33. Lauren K. Regula, Richard Harris, Fang Wang, Jayne F. Koellhoffer, Chelsea D. Higgins, Kartik Chandran, Jianmin Gao, Mark E. Girvin, and Jonathan R. Lai*, “Conformation and Lipid-Binding Properties of Peptides Corresponding to the Ebolavirus GP2 Membrane-Proximal External Region,” Biochemistry, 2013, 52, 3393-404.
32. Jianmin Gao* and Hong Zheng , “Illuminating the lipidome to advance biomedical research: peptide-based probes of membrane lipids,” Future Med. Chem. 2013, 5, 947-59.
31. Christopher Pace and Jianmin Gao*, “Exploring and Exploiting Polar-p Interactions with Fluorinated Aromatic Amino Acids,” Acc. Chem. Res. 2013, 46, 907-15.
30. Christopher Pace, Diane Kim and Jianmin Gao*, “Experimental Evaluation of CH—π Interactions in a Protein Core,” Chem. Euro. J. 2012, 18, 5832-6.
29. Yue Zhao and Jianmin Gao*, “Split Ligand for Lanthanide Binding: Facile Evaluation of Dimerizing Proteins,” Chem. Comm. 2012, 48, 2997-9.
28. Luoheng Qin, Christopher Sheridan and Jianmin Gao*, “Synthesis of Tetrafluorinated Aromatic Amino Acids with Distinct Signatures in 19F-NMR,” Org. Lett. 2012, 14, 528-31.
27. Fang Wang, Luoheng Qin, Christopher J. Pace, Patrick Wong, Ryan Malonis and Jianmin Gao*, “Solubilized Gramicidin A as Potential Systemic Antibiotics,” ChemBioChem 2012, 13, 51-5.
26. Christopher Pace, Hong Zheng, Ruben Mylvaganam, Diane Kim and Jianmin Gao*, “Stacked Fluoroaromatics as Supramolecular Synthons for Programming Protein Dimerization Specificity,” Angew. Chem., Int. Ed. 2012, 51, 103-7.
25. Hong Zheng, Fang Wang, Qin Wang and Jianmin Gao*, “Cofactor-Free Detection of Phosphatidylserine with Cyclic Peptides Mimicking Lactadherin,” J. Am. Chem. Soc. 2011, 133, 15280-3.
24. Christopher Pace, Qiongying Huang, Fang Wang, Kanwal S. Palla, Amelia A. Fuller and Jianmin Gao*, “A FlAsH-tetracysteine Assay for Quantifying the Association and Orientation of Transmembrane a-Helices,” ChemBioChem 2011, 12, 1018-22.
23. Fang Wang, Luoheng Qin, Patrick Wong and Jianmin Gao*, “Facile Synthesis of Tetrafluorotyrosine and Its Application in pH Triggered Membrane Lysis,” Org. Lett. 2011, 13, 236-9. This paper is highlighted in the recent ACS virtual issue on Peptide Chemistry.
22. Hong Zheng and Jianmin Gao*, “Highly Specific Heterodimerization Mediated by Quadrupole Interactions,” Angew. Chem., Int. Ed. 2010, 49, 8635-9. This article was rated as a Very Important Paper. See highlight by Kros et al. “Introducing Quadrupole Interactions into the Peptide Design Toolkit,” Angew. Chem., Int. Ed. 2010, 49, 8570-2.
21. Luoheng Qin, Julian Vastl and Jianmin Gao*, “Highly Sensitive Amyloid Detection Enabled by Thioflavin T Dimers,” Mol. Biosyst. 2010, 6, 1791-5.
20. Hong Zheng, Kristofer Comeforo and Jianmin Gao*, “Expanding the Fluorous Arsenal: Tetrafluorinated Phenylalanines for Protein Design,” J. Am. Chem. Soc. 2009, 131, 18-9.
19. Jianmin Gao, Daryl A. Bosco, Evan T. Powers, and Jeffery W. Kelly*, “Localized Thermodynamic Coupling between Hydrogen Bonding and Microenvironment Polarity Significantly Stabilizes Proteins,” Nat. Struct. Mol. Biol. 2009, 16, 684-90.
18. Michelle R. Bunagan, Jianmin Gao, Jeffery W. Kelly*, and Feng Gai* “Probing the Folding Transition State Structure of the Villin Headpiece Subdomain via Sidechain and Backbone Mutagenesis,” J. Am. Chem. Soc. 2009, 131, 7470-6.
17. Marcus Jager, Songpon Deechongkit, Edward K. Koepf, Houbi Nguyen, Jianmin Gao, Evan T. Powers, Martin Gruebele, and Jeffery W. Kelly*, “Understanding the Mechanism of b-sheet Folding from a Chemical and Biological Perspective,” Biopolymers 2008, 90, 751-8.
16. Jianmin Gao and Jeffery W. Kelly*, “Towards Quantification of Protein Backbone-Backbone Hydrogen Bonding Energies: An Energetic Analysis of an Amide-to-Ester Mutation in an a-Helix within a Protein,” Protein Sci. 2008, 1096-101.
15. Yanwen Fu, Jianmin Gao, Jan Bieschke, Maria, A. Dendle, and Jeffery W. Kelly*, “Amide-to-E-Olefin versus Amide-to-Ester Backbone H-Bond Perturbations: Evaluating the Repulsive Lone Pair-Lone Pair interaction for Extracting H-Bond Energies,” J. Am. Chem. Soc. 2006, 128, 15948-9.
14. Yan Zhang, Youngjun Kim, Nicolas Genoud, Jianmin Gao, Jeffery W. Kelly, Samuel L. Pfaff, Gordon N. Gill, Jack E. Dixon, and Joseph P. Noel* “Determinants for Dephosphorylation of the RNA Polymerase II C-terminal Domain by Scp1,” Mol. Cell. 2006, 24, 759-70.
13. Sarah K. Jarchow-Choy, Andrew T. Krueger, Haibo Liu, Jianmin Gao and Eric T. Kool*, “Fluorescent xDNA Nucleotides as Efficient Substrates for a Template-independent Polymerase,” Nucleic Acids Res.2011, 39, 1586-94.
12. Haige Lu, Andrew T. Kruger, Jianmin Gao, Haibo Liu and Eric T. Kool*, “Toward a Designed Genetic System with Biochemical Function: Polymerase Synthesis of Single and Multiple Size-Expanded DNA Base Pairs,” Org. Biomol. Chem. 2010, 8, 2704-10.
11. James C. Delaney, Jianmin Gao, Haibo Liu, Nidhi Shrivastav, John M. Essigmann* and Eric T. Kool*, “Efficient Replication Bypass of Size-expanded DNA Base Pairs in Bacterial Cells,” Angew. Chem., Int. Ed. 2009, 48, 4254-7.
10. James N. Wilson, Jianmin Gao, and Eric T. Kool*, “Oligodeoxyfluorosides: Strong Sequence Dependence of Fluorescence Emission,” Tetrahedron 2007, 63, 3427-33.
9. Stephen R. Lynch, Haibo Liu, Jianmin Gao, and Eric T. Kool*, “Toward a Designed, Functioning Genetic System With Expanded-size Base Pairs: Solution Structure of the 8-Base xDNA Double Helix,” J. Am. Chem. Soc. 2006, 128, 14704-11 (This work is featured in a Research Highlight in Nature, 2006, 444, 5 and highlighted in the News and Views in Nature, 2006, 444, 554-5) .
8. Jianmin Gao†, Haibo Liu†, and Eric T. Kool*, “Assembly of the Complete Eight-Base Artificial Genetic Helix, xDNA, and Its Interaction with the Natural Genetic System,”Angew. Chem., Int. Ed. 2005, 44, 3118-22. (†co first author. This paper is featured in Chemical and Engineering News, 2005, 83, 23.)
7. Haibo Liu, Jianmin Gao, and Eric T. Kool*, “Helix-forming Properties of Size-expanded DNA (xDNA), an Alternative Four-base Genetic Form,” J. Am. Chem. Soc. 2005, 127, 1396-402.
6. Haibo Liu, Jianmin Gao, and Eric T. Kool*, “Size-expanded Analogues of dG and dC. Synthesis and Pairing Properties in DNA,” J. Org. Chem. 2005, 70, 639-47.
5. Jianmin Gao, Soichiro Watanabe, and Eric T. Kool*, “Modified DNA Analogues That Sense Light Exposure with Color Changes,” J. Am. Chem. Soc. 2004, 126, 12748-9. (This work is featured in a Research Highlight in Nature Methods 2004, 1, 100-1.)
4. Jianmin Gao, Haibo Liu, and Eric T. Kool*, “Expanded-Size Bases in Naturally Sized DNA: Evaluation of Steric Effects in Watson-Crick Pairing,” J. Am. Chem. Soc. 2004, 126, 12748-9.
3. Haibo Liu, Jianmin Gao, Y.David Saito, Lystranne Maynard, Eric T. Kool*, “Toward a New Genetic System with Expanded Dimensions: Size-expanded Analogues of Deoxyadenosine and Thymidine,” J. Am. Chem. Soc. 2004, 126, 1102-9.
2. Haibo Liu, Jianmin Gao, Stephen Lynch, Y.David Saito, Lystranne Maynard, Eric T. Kool*, “A Four-base-pair Genetic Helix with Expanded Size,” Science 2003, 302, 868-71. (This paper is reported in Chemical and Engineering News 2003, 81, 3, highlighted in Angew. Chem., Int. Ed. 2004, 43, 1625-6, and featured in ChemBioChem 2004, 5, 765-7.)
1. Jianmin Gao, Christoph Strassler, Deborah Tahmassebi, and Eric T. Kool*, “Libraries of Composite Polyfluors Built from Fluorescent Deoxyribosides,” J. Am. Chem. Soc., 2002, 124, 11590-1.