Publications

65. "Precise manipulation of site and stoichiometry of capsid modification enables optimization of functional adeno-associated virus conjugates" SB Erickson, Q Pham, X Cao, J Glicksman, RE Kelemen, SS Shahraeini, S Bodkin, Z Kiyam & A Chatterjee. bioRxiv DOI: 10.1101/2023.09.07.556719 (2023)       

 

64. "Virus-assisted directed evolution of biomolecules" D Jewel, Q Pham & A Chatterjee. Current Opinion in Chemical Biology DOI: 10.1016/j.cbpa.2023.102375 (2023)       

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase enzymes to include non-α-amino acids in vitro and in vivo" R Fricke, CV Swenson, LT Roe, NX Hamlish, B Shah, Z Zhang, E Ficaretta, O Ad, S Smaga, CL Gee, A Chatterjee & A Schepartz. Nature Chemistry DOI: 10.1038/s41557-023-01224-y (2023)       

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

62. "Chemical Tagging of Bioactive Amides by Cooperative Catalysis: Applications in the Syntheses of Drug Conjugates" C Zhao, Y Wang, Q Pham, C Dai, A Chatterjee, M Wasa. Journal of the American Chemical Society DOI: 10.1021/jacs.3c00169 (2023)       

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

61. "Photoredox-Catalyzed Labeling of Hydroxyindoles with Chemoselectivity (PhotoCLIC) for Site-Specific Protein Bioconjugation" SJS Roy, C Loynd, D Jewel, SE Canarelli, ED Ficaretta, QA Pham, E Weerapana, A Chatterjee. Angewandte Chemie International Edition DOI: 10.1002/anie.202300961 (2023)       

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

60. "An Efficient Opal-Suppressor Tryptophanyl Pair Creates New Routes for Simultaneously Incorporating up to Three Distinct Noncanonical Amino Acids into Proteins in Mammalian Cells" AO Osgood, Y Zheng, SJS Roy, N Biris, M Hussain, C Loynd, D Jewel, JS Italia, A Chatterjee. Angewandte Chemie International Edition DOI: g/10.1002/anie.202219269 (2023)       

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

59. "Virus-assisted directed evolution of enhanced suppressor tRNAs in mammalian cells" D Jewel, RE Keleman, RL Huang, Z Zhu, B Sundaresh, X Cao, K Malley, Z Huang, M Pasha, J Anthony, T van Opijnen, A Chatterjee. Nature Methods, DOI: 10.1038/s41592-022-01706-w;  bioRxiv. DOI: 10.1101/2022.01.21.477302 (2023)       

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

58. "Selective Incorporation of 5-Hydroxytryptophan Blocks Long Range Electron Transfer in Oxalate Decarboxylase" AJ Pastore, A Montoya, M Kamat, KB Basso, JS Italia, A Chatterjee, M Drosou, DA Pantazis, A Angerhofer. Protein Science, DOI: 10.1002/pro.4537;  bioRxiv, DOI: 10.1101/2022.01.21.477302 (2022)       

57. "Substitution of the sole tryptophan of the cupredoxin, amicyanin, with 5-hydroxytryptophan alters fluorescence properties and energy transfer to the type 1 copper site" AJ Pastore, E Ficaretta, A Chatterjee, VL Davidson. Journal of Inorganic Biochemistry, 234, 111895. DOI: 10.1016/j.jinorgbio.2022.111895 (2022)       

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

56. "A facile platform to engineer E. coli tyrosyl-tRNA synthetase adds new chemistries to the eukaryotic genetic code, including a phosphotyrosine mimic" KT Grasso, SJS Roy, AO Osgood, MJR Yeo, C Soni, CM Hillenbrand, ED Ficaretta, A Chatterjee. ACS Central Science, 8, 4, 483-492. DOI: 10.1021/acscentsci.1c01465; bioRxiv. DOI: 10.1101/2021.11.28.470256 (2022)      

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

55. "Uncovering post-translational modification-associated protein–protein interactions" S Wang, AO Osgood, A Chatterjee. Current Opinion in Structural Biology, 74, 102352. DOI: 10.1016/j.sbi.2022.102352 (2022)     

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

54. "A Robust Platform for Unnatural Amino Acid Mutagenesis in E. coli Using the Bacterial Tryptophanyl-tRNA synthetase/tRNA pair" ED Ficaretta, CSS Wrobel, SJS Roy, SB Erickson, JS Italia, A Chatterjee*. Journal of Molecular Biology, 434, 8, 167304. DOI: 10.1016/j.jmb.2021.167304 (2021)     

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

53. "Genetic Code Expansion in the Engineered Organism Vmax X2: High Yield and Exceptional Fidelity" S Santiago González, O Ad, B Shah, Z Zhang, X Zhang, A Chatterjee, A Schepartz*. ACS Central Science, 7, 9, 1500-1507. DOI: 10.1021/acscentsci.1c00499 (2021)  

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

52. "Rewriting the genetic code" D Jewel, A Chatterjee. Science, 372, 6546, 1040-1041. DOI: 10.1126/science.abi9892 (2021) 

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

51. "An Emerging Link between Robustness and Evolvability in Directed Protein Evolution"  KT Grasso, A Chatterjee*. Biochemistry,  60, 17, 1325-1326. DOI: 10.1021/acs.biochem.1c00142 (2021) 

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

50. "Structural robustness affects the engineerability of aminoacyl-tRNA synthetases for genetic code expansion." KT Grasso, MJR Yeo, CM Hillenbrand, ED Ficaretta, JS Italia, RL Huang, A Chatterjee*. Biochemistry, 60, 7, 489-493. (Cover article) DOI: 10.1021/acs.biochem.1c00056 (2021)  

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

49. "Site-specific incorporation of citrulline into proteins in mammalian cells." S Mondal, S Wang, Y Zheng, S Sen, A Chatterjee*, PR Thompson*. Nature Communications, 12, 45. DOI: 10.1038/s41467-020-20279-w (2021)    

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

48. "Genetically encoded protein sulfation in mammalian cells." JS Italia, JC Peeler, CM Hillenbrand, C Latour, E Weerapana*, A Chatterjee*. Nature Chemical Biology, 16, 379-382. DOI:10.1038/s41589-020-0493-1 (2020)   

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

47. "An orthogonal seryl-tRNA synthetase/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli."  C Zambaldo, M Koh, F Nasertorabi, GW Han, A Chatterjee*, RC Stevens*, PG Schultz*. Bioorganic & Medicinal Chemistry, 28 (20), 115662 (2020) 

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

46. "Creation of Bacterial Cells with 5-Hydroxytryptophan as a 21st Amino Acid Building Block."  Y Chen, J Tang, L Wang, Z Tian, A Cardenas, X Fang, A Chatterjee, H Xiao. Chem, 6(10), 2717-2727 (2020)   

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

45. "Generation of Recombinant Mammalian Selenoproteins through Genetic Code Expansion with Photocaged Selenocysteine." JC Peeler, RE Kelemen, M Abo, LC Edinger, J Chen, A Chatterjee*, E Weerapana*. ACS Chemical Biology, 15, 1535–1540 bioRxiv, DOI: 10.1101/759662 (2020) 

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

44. "Mutually orthogonal nonsense-suppression systems and conjugation chemistries for precise protein labeling at up to three distinct sites." JS Italia, PS Addy, SB Erickson, JC Peeler, E Weerapana, A Chatterjee*. Journal of the American Chemical Society, 141 (15), 6204-6212. DOI: 10.1021/jacs.8b12954 (2019) 

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

43. "A 'Quenchergenic' Chemoselective Protein Labeling Strategy." PS Addy, Y Zheng, JS Italia, A Chatterjee*. ChemBioChem, 20 (13), 1659-1663. (VIP article) DOI: 10.1002/cbic.201800817 (2019)  

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

42. Synthesis and characterization of an unnatural boron and nitrogen-containing tryptophan analogue and its incorporation into proteins. K Boknevitz, JS Italia, B Li, A Chatterjee*, Shih-Yuan Liu*. Chemical Science, 10, 4994. (2019)  

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

41. "Labeling Proteins at Site-Specifically Incorporated 5-Hydroxytryptophan Residues Using a Chemoselective Rapid Azo-Coupling Reaction." PS Addy, SB Erickson, JS Italia, A Chatterjee*. Bioconjugation, 239-251. (2019)  

 

40. "Synthesis at the Interface of Virology and Genetic Code Expansion." RE Kelemen, SB Erickson, A Chatterjee*. Current Opinion in Chemical Biology, 46, 164. DOI: 10.1016/j.cbpa.2018.07.015 (2018)     

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

39. "Resurrecting the Bacterial Tyrosyl-tRNA Synthetase/tRNA Pair for Expanding the Genetic Code of Both E. coli and Eukaryotes." JS Italia, C Latour, CJJ Wrobel, A Chatterjee*. Cell Chemical Biology, 25, 1304-1312. DOI: 10.1016/j.chembiol.2018.07.002 (2018)  

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

38. "An Oxidative Bioconjugation Strategy Targeted to a Genetically Encoded 5‐hydroxytryptophan." PS Addy, JS Italia, A Chatterjee*. ChemBioChem, 19, 1375. (VIP article, highlighted by ChemistryViews) DOI: 10.1002/cbic.201800111 (2018)    

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

37. "Capturing post-translational modification-triggered protein-protein interactions using dual noncanonical amino acid mutagenesis." Y Zheng, MJ Gilgenast, S Hauc, A Chatterjee*. ACS Chemical Biology, 13 (5), 1137. DOI: 10.1021/acschembio.8b00021 (2018)    

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

36. "Production and Chemoselective Modification of Adeno-Associated Virus Site-Specifically Incorporating an Unnatural Amino Acid Residue into Its Capsid." RE Kelemen, SB Erickson, A Chatterjee*. Methods in Molecular Biology,1728, 313. DOI: 10.1007/978-1-4939-7574-7_20. (2018)     

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

35. "Expanding the scope of single and double noncanonical amino acid mutagenesis in mammalian cells using orthogonal polyspecific leucyl-tRNA synthetases." Y Zheng, R Mukherjee, MA Chin, P Igo, MJ Gilgenast, A Chatterjee*. Biochemistry, 57 (4), 441. DOI: 10.1021/acs.biochem.7b00952. (2018)                                                                                                                                                          

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

34. "Establishing an Interdisciplinary Outreach Program at the Interface of Biology, Chemistry, and Materials Science." JA Byers,* E Weerapana, A Chatterjee. ACS Symposium Series, 1259, 51–68. DOI: 10.1021/bk-2017-1259.ch005. (2017)      

 

33. "Defining the current scope and limitations of dual noncanonical amino acid mutagenesis in mammalian cells." Y Zheng, PS Addy, R Mukherjee, A Chatterjee*. Chemical Science, 8, 7211. DOI: 10.1039/C7SC02560B (2017)       

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

32. "A Chemoselective Rapid Azo-Coupling Reaction (CRACR) for Unclickable Bioconjugation." PS Addy, SB Erickson, JS Italia, A Chatterjee*. Journal of the American Chemical Society, 139 (34), 11670. (Highlighted by JACS Spotlights, Faculty of 1000, Nature Chemical Biology) DOI: 10.1021/jacs.7b05125 (2017)                                                                                                                                                                                                       

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

31. "A Role for Chemistry" (Invited Commentary on "What Is the Role of Circuit Design in the Advancement of Synthetic Biology'). A Chatterjee. Cell Systems, 4 (6), 580. (2017)      

 

30. "Expanding the genetic code of mammalian cells" (Invited Review). JS Italia, Y Zheng, RE Kelemen, SB Erickson, PS Addy, A Chatterjee*. Biochemical Society Transactions, 45 (2), 555-562. DOI: 10.1042/BST20160336 (2017)        

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

29. "Precise photoremovable perturbation of a virus-host interaction." SB Erickson, R Mukherjee, RE Kelemen, CJJ Wrobel, X Cao, A Chatterjee*. Angewandte Chemie International Edition, 56, 4234-4237. DOI: 10.1002/anie.201700683. (2017)   

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

28. "An orthogonalized platform for genetic code expansion in both bacteria and eukaryotes." JS Italia, PS Addy, CJJ Wrobel, LA Crawford, MJ Lajoie, Y Zheng, A Chatterjee*. Nature Chemical Biology, 13, 446-450. DOI: 10.1038/nchembio.2312. (2017)               

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

27. "A unique genetically encoded FRET pair in mammalian cells." AL Mitchell, PS Addy, MA Chin, A Chatterjee*. ChemBioChem, 18, 511-514. DOI: 10.1002/cbic.201600668. (2017)     

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

26. "Virus-enabled optimization and delivery of the genetic machinery for efficient unnatural amino acid mutagenesis in mammalian cells and tissues." Y Zheng, TL Lewis, P Igo, F Polleux, A Chatterjee*. ACS Synthetic Biology, 6, 13-18. (Cover article) DOI: 10.1021/acssynbio.6b00092. (2017)

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

25. "A Precise Chemical Strategy To Alter the Receptor Specificity of the Adeno‐Associated Virus." RE Kelemen, R Mukherjee, X Cao, SB Erickson, Y Zheng, A Chatterjee*. Angewandte Chemie International Edition, 55, 10645-10649 doi: 10.1002/anie.201604067. (2016)

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

24. "Performance of optimized noncanonical amino acid mutagenesis systems in the absence of release factor 1." Y Zheng, MJ Lajoie, JS Italia, MA Chin, GM Church, A Chatterjee*. Molecular BioSystems 12 (6), 1746-1749 (Hot Article, Inside Cover) DOI: 10.1039/C6MB00070C (2016)                                                      

 

63. "Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase

Prior to Boston College                    

23. "A Bacterial Strain with a Unique Quadruplet Codon Specifying Non‐native Amino Acids." A Chatterjee, MJ Lajoie, H Xiao, GM Church, PG Schultz. ChemBioChem 15 (12), 1782-1786 (2014)                                                                                

22. "Genetic incorporation of multiple unnatural amino acids into proteins in mammalian cells." H Xiao,a A Chatterjee,a S Choi, KM Bajjuri, SC Sinha, PG Schultz. Angewandte Chemie International Edition 52 (52), 14080-14083 (2013) aequal contribution                                                                                        

21. "A genetically encoded fluorescent probe in mammalian cells." A Chatterjee, J Guo, HS Lee, PG Schultz. Journal of the American Chemical Society 135 (34), 12540-12543 (2013)                                                                                                  

20. "Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells." A Chatterjee, H Xiao, M Bollong, HW Ai, PG Schultz. Proceedings of the National Academy of Sciences 110 (29), 11803-11808 (2013)             

19. "A Tryptophanyl‐tRNA Synthetase/tRNA Pair for Unnatural Amino Acid Mutagenesis in E. coli." A Chatterjee, H Xiao, PY Yang, G Soundararajan, PG Schultz. Angewandte Chemie International Edition 52 (19), 5106-5109 (2013)                 

18. "A versatile platform for single-and multiple-unnatural amino acid mutagenesis in Escherichia coli." A Chatterjee, SB Sun, JL Furman, H Xiao, PG Schultz. Biochemistry 52 (10), 1828-1837 (2013)                                                                   

17. "Site‐Specific Incorporation of ε‐N‐Crotonyllysine into Histones." CH Kim, M Kang, HJ Kim, A Chatterjee, PG Schultz. Angewandte Chemie International Edition 51 (29), 7246-7249  (2012)                                                                      

16. "Evolution of multiple, mutually orthogonal prolyl-tRNA synthetase/tRNA pairs for unnatural amino acid mutagenesis in Escherichia coli." A Chatterjee, H Xiao, PG Schultz. Proceedings of the National Academy of Sciences  109(37), 14841–14846 (2012)                                                                                                      

15. "Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase." A Chatterjee, ND Abeydeera, S Bale, PJ Pai, PC Dorrestein, DH Russell, SE Ealick, TP Begley. Nature 478 (7370), 542-546 (2011)                                                  

14. "A Missing Enzyme in Thiamin Thiazole Biosynthesis: Identification of TenI as a Thiazole Tautomerase." AB Hazra, Y Han, A Chatterjee, Y Zhang, RY Lai, SE Ealick, TP Begley. Journal of the American Chemical Society 133 (24), 9311–9319 (2011)                                                                                                                 

13. "A 'Radical Dance' in Thiamin Biosynthesis: Mechanistic Analysis of the Bacterial Hydroxymethylpyrimidine Phosphate Synthase." A Chatterjee, AB Hazra, S Abdelwahed, DG Hilmey, TP Begley. Angewandte Chemie International Edition 49 (46), 8653–8656 (2010)                                                                                     

12. "Domain organization in Candida glabrata THI6, a bifunctional enzyme required for thiamin biosynthesis in eukaryotes." D Paul, A Chatterjee, TP Begley, SE Ealick. Biochemistry 49 (45), 9922-9934 (2010)                                 

11. "Biosynthesis of the thiamin thiazole in Bacillus subtilis: identification of the product of the thiazole synthase-catalyzed reaction." A Hazra, A Chatterjee, TP Begley. Journal of the American Chemical Society 131 (9), 3225-3229 (2009)         

10. "Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily." A Chatterjee, Y Li, Y Zhang, TL Grove, M Lee, C Krebs, SJ Booker, TP Begley, SE Ealick. Nature chemical biology 4 (12), 758-765 (2008)                                                                                                                                  

9. "Biosynthesis of the thiamin-thiazole in eukaryotes: identification of a thiazole tautomer intermediate." A Chatterjee, FC Schroeder, CT Jurgenson, SE Ealick, TP Begley. Journal of the American Chemical Society 130 (34), 11394-11398 (2008)                                                                                                                               

8. "Cofactor biosynthesis—still yielding fascinating new biological chemistry." TP Begley, A Chatterjee, JW Hanes, A Hazra, SE Ealick. Current opinion in chemical biology 12 (2), 118-125 (2008)                                                                 

7. "Mechanistic studies on pyridoxal phosphate synthase: the reaction pathway leading to a chromophoric intermediate." JW Hanes, KE Burns, DG Hilmey, A Chatterjee, PC Dorrestein, TP Begley. Journal of the American Chemical Society 130 (10), 3043-3052 (2008)                                                                                 

6. "Biosynthesis of thiamin thiazole in eukaryotes: conversion of NAD to an advanced intermediate." A Chatterjee, CT Jurgenson, FC Schroeder, SE Ealick, TP Begley. Journal of the American Chemical Society 129 (10), 2914-2922 (2007)                                                                                                                        

5. "Structural insights into the function of the thiamin biosynthetic enzyme Thi4 from Saccharomyces cerevisiae." CT Jurgenson, A Chatterjee, TP Begley, SE Ealick. Biochemistry 45 (37), 11061-11070 (2006)                                           

4. "Thiamin Biosynthesis in Eukaryotes: Characterization of the Enzyme-Bound Product of Thiazole Synthase from Saccharomyces cerevisiae and Its Implications in Thiazole Biosynthesis." A Chatterjee, CT Jurgenson, FC Schroeder, SE Ealick, TP Begley. Journal of the American Chemical Society 128 (22), 7158-7159 (2006)                     

3. "Biosynthesis of Thiamin Thiazole: Determination of the Regiochemistry of the S/O Acyl Shift by Using 1, 4‐Dideoxy‐D‐xylulose‐5‐phosphate." A Chatterjee, X Han, FW McLafferty, TP Begley. Angewandte Chemie International Edition  45 (21), 3507-3510 (2006)                                                                                          

2. "Simultaneous kinetic characterization of multiple protein forms by top down mass spectrometry." H Zhai, PC Dorrestein, A Chatterjee, TP Begley, FW McLafferty. Journal of the American Society for Mass Spectrometry 16 (7), 1052-1059 (2005)                                                                                                          

1. "Thiamin biosynthesis in Bacillus subtilis: structure of the thiazole synthase/sulfur carrier protein complex." EC Settembre, PC Dorrestein, H Zhai, A Chatterjee, FW McLafferty, TP Begley, SE Ealick. Biochemistry , 43 (37), 11647-11657 (2004)

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