Biology Department Faculty
Thomas N. Seyfried
Professor
Thomas N. Seyfried
Ph.D.
Contact
Higgins Hall 514
Telephone: 617-552-3563
Email: thomas.seyfried@bc.edu
ORCID 0000-0003-1491-3989
Education
- Ph.D., University of Illinois, Urbana-Champaign
Research Interests
Gene-Environmental Interactions, Lipid Biochemistry, Neurodegeneration, Ganglioside Storage Diseases, Epilepsy, Cancer, Metabolism, Brain Tumors, Autism, Ketogenic Diets, Dietary Energy Restriction
Department
Selected Publications
- Doczi, J., Noemi Karnok, David Bui, Victoria Azarov, Gergely Pallag, Sara Nazarian, Bence Czumbel, Thomas N. Seyfried, Christos Chinopoulos. Viability of HepG2 and MCF-7 cells is not correlated with mitochondrial bioenergetics. Sci Rep. 2023; 13: 10822. Published online 2023 Jul 4. doi: 10.1038/s41598-023-37677-x
- Seyfried, TN., Purna Mukherjee, Derek C. Lee, Linh Ta, Loren Nations. Case report: Resolution of malignant canine mast cell tumor using ketogenic metabolic therapy alone. Front Nutr. 2023; 10: 1157517. Published online 2023 Mar 28. doi: 10.3389/fnut.2023.1157517
- Seyfried TN. The effects of diet on prostate cancer outcomes. Nat Rev Urol. 2022 Jul;19(7):389-390. doi: 10.1038/s41585-022-00612-2.PMID: 35676538.
- Seyfried TN, Arismendi-Morillo G, Zuccoli G, Lee DC, Duraj T, Elsakka AM, Maroon JC, Mukherjee P, Ta L, Shelton L, D'Agostino D, Kiebish M, Chinopoulos C. Metabolic management of microenvironment acidity in glioblastoma. Front Oncol. 2022 Aug 17;12:968351. doi: 10.3389/fonc.2022.968351. eCollection 2022.PMID: 36059707
- Seyfried TN, Shivane AG, Kalamian M, Maroon JC, Mukherjee P, Zuccoli G. Ketogenic Metabolic Therapy, Without Chemo or Radiation, for the Long-Term Management of IDH1-Mutant Glioblastoma: An 80-Month Follow-Up Case Report. Front Nutr. 2021 May 31;8:682243. doi:10.3389/fnut.2021.682243. eCollection 2021.PMID: 34136522
- Seyfried TN, Mukherjee P, Lee DC, Ta L, Nations L. Case report: Resolution of malignant canine mast cell tumor using ketogenic metabolic therapy alone. Front Nutr. 2023 Mar 28;10:1157517. doi: 10.3389/fnut.2023.1157517. eCollection 2023.PMID: 37057065
- Seyfried TN, Arismendi-Morillo G, Zuccoli G, Lee DC, Duraj T, Elsakka AM, Maroon JC, Mukherjee P, Ta L, Shelton L, D'Agostino D, Kiebish M, Chinopoulos C. Answer to the critical remarks to the article by Khodabakhshi and colleagues reporting results from a randomized study on ketogenic diet. Front Oncol. 2022 Aug 17;12:968351. doi: 10.3389/fonc.2022.968351. PMID: 36059707
- Evangeliou AE, Spilioti MG, Vassilakou D, Goutsaridou F, Seyfried TN. Restricted Ketogenic Diet Therapy for Primary Lung Cancer With Metastasis to the Brain: A Case Report. Cureus. 2022 Aug 2;14(8):e27603. doi: 10.7759/cureus.27603. eCollection 2022 Aug.PMID: 36059366
- Pallag G, Nazarian S, Ravasz D, Bui D, Komlódi T, Doerrier C, Gnaiger E, Seyfried TN, Chinopoulos C. Proline Oxidation Supports Mitochondrial ATP Production When Complex I Is Inhibited. Int J Mol Sci. 2022 May 4;23(9):5111. doi: 10.3390/ijms23095111.PMID: 35563503
- Duraj T, Carrión-Navarro J, Seyfried TN, García-Romero N, Ayuso-Sacido A.Metabolic therapy and bioenergetic analysis: The missing piece of the puzzle.. Mol Metab. 2021 Dec;54:101389. doi: 10.1016/j.molmet.2021.101389. Epub 2021 Nov 5.PMID: 34749013
- Seyfried TN, Chinopoulos C. Metabolites. Can the Mitochondrial Metabolic Theory Explain Better the Origin and Management of Cancer than Can the Somatic Mutation Theory? 2021 Aug 25;11(9):572. doi: 10.3390/metabo11090572.PMID: 34564387
- Jiang Y, Yang X, Dong C, Lu Y, Yin H, Xiao B, Yang X, Chen W, Cheng W, Tian H, Guo L, Hu X, Fang H, Chen W, Li Z, Zhou W, Sun W, Guo X, Li S, Lin Y, He R, Chen X, Liu D, Zhang M, Zhang Y, Zhao H, Zheng P, Seyfried TN, Hoffman RM, Jia W, Ji G, Jia L. Five-day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers without toxicity in a clinical trial of normal-weight individuals. Clin Transl Med. 2021 Aug;11(8):e502. doi: 10.1002/ctm2.502.PMID: 34459130
- Gross AL, Gray-Edwards HL, Bebout CN, Ta NL, Nielsen K, Brunson BL, Mercado KRL, Osterhoudt DE, Batista AR, Maitland S, Seyfried TN, Sena-Esteves M, Martin DR. Intravenous delivery of adeno-associated viral gene therapy in feline GM1 gangliosidosis. Brain. 2021 Aug 19:awab309. doi: 10.1093/brain/awab309. Online ahead of print.PMID: 34410345.
- Gabriele VR, Mazhabi RM, Alexander N, Mukherjee P, Seyfried TN, Nwaji N, Akinoglu EM, Mackiewicz A, Zhou G, Giersig M, Naughton MJ, Kempa K.
Light- and Melanin Nanoparticle-Induced Cytotoxicity in Metastatic Cancer Cells. Pharmaceutics. 2021 Jun 26;13(7):965. doi: 10.3390/pharmaceutics13070965.PMID: 34206894 - İyikesici MS, Slocum AK, Winters N, Kalamian M, Seyfried TN. Metabolically Supported Chemotherapy for Managing End-Stage Breast Cancer: A Complete and Durable Response. Cureus. 2021 Apr 26;13(4):e14686. doi: 10.7759/cureus.14686.PMID: 33927959.
- Lee TS, Li AY, Rapuano A, Mantis J, Eid T, Seyfried TN, de Lanerolle NC Gene expression in the epileptic (EL) mouse hippocampus. Neurobiol Dis. 2021 Jan;147:105152. doi: 10.1016/j.nbd.2020.105152.
- Seyfried TN, Arismendi-Morillo G, Mukherjee P, Chinopoulos C. On the Origin of ATP Synthesis in Cancer. iScience. 2020 Nov 2;23(11):101761. doi: 10.1016/j.isci.2020.101761.
- Thomas N. Seyfried, Laura Shelton, Gabriel Arismendi‑Morillo, Miriam Kalamian, Ahmed Elsakka, Joseph Maroon, Purna Mukherjee. Provocative Question: Should Ketogenic Metabolic Therapy Become the Standard of Care for Glioblastoma? Springer Science+Business Media, LLC, part of Springer Nature 2019 Received: 22 January 2019 / Revised: 3 April 2019 / Accepted: 4 April 2019
- Christos Chinopoulos and Thomas N. Seyfried. Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis. ASN Neuro | (2019) 2:200 | https://doi.org/10.1038/s42003-019-0455-x | www.nature.com/commsbio
- Purna Mukherjee, Zachary M. Augur, Mingyi Li, Collin Hill, Bennett Greenwood, Marek A. Domin, Gramoz Kondakci, Niven R. Narain, Michael A. Kiebish, Roderick T. Bronson, Gabriel Arismendi-Morillo, Christos Chinopoulos & Thomas N. Seyfried. Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma. COMMUNICATIONS BIOLOGY | (2019) 2:200 | https://doi.org/10.1038/s42003-019-0455-x | www.nature.com/commsbio
- Zachary M. Augur, Catherine M. Doyle, Mingyi Li, Purna Mukherjee and Thomas N. Seyfried. Nontoxic Targeting of Energy Metabolism in Preclinical VM-M3 Experimental Glioblastoma Front. Nutr., 05 October 2018.
- Taus LJ, Flores RE, Seyfried TN. Quantification of metastatic load in a syngeneic murine model of metastasis. Cancer Lett. 2017 Oct 1;405:56-62. doi: 10.1016/j.canlet. 2017.07.011.
- Klement RJ, Feinman RD, Gross EC, Champ CE, D'Agostino DP, Fine EJ, Kämmerer U, Poff A, Rho JM, Seyfried TN, Scheck AC. Need for new review of article on ketogenic dietary regimes for cancer patients. Med Oncol. 2017 Jun;34(6):108. doi: 10.1007/s12032-017-0968-4.
- Arismendi-Morillo G, Castellano-Ramírez A, Seyfried TN. Ultrastruct Pathol. 2017 May-Jun;41(3):234-244. doi: Ultrastructural characterization of the Mitochondria-associated membranes abnormalities in human astrocytomas: Functional and therapeutics implications. 10.1080/01913123.2017.1300618.
- Puchowicz MA, Seyfried TN. Novel ketone body therapy for managing Alzheimer's disease: An Editorial Highlight for Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease. J Neurochem. 2017 Apr;141(2):162-164. doi: 10.1111/jnc.
- Seyfried TN, Yu G, Maroon JC, D'Agostino DP. Press-pulse: a novel therapeutic strategy for the metabolic management of cancer. Nutr Metab (Lond). 2017 Feb 23;14:19. doi: 10.1186/s12986-017-0178-2. eCollection 2017. PMID: 28250801
- Chen E, Kiebish MA, McDaniel J, Gao F, Narain NR, Sarangarajan R, Kacso G, Ravasz D, Seyfried TN, Adam-Vizi V, Chinopoulos C. The total and mitochondrial lipidome of Artemia franciscana encysted embryos. Biochim Biophys Acta. 2016 Nov;1861(11):1727-1735. doi: 10.1016/j.bbalip.2016.08.007.
- Schneider JS, Seyfried TN, Choi HS, Kidd SK. Intraventricular Sialidase Administration Enhances GM1 Ganglioside Expression and Is Partially Neuroprotective in a Mouse Model of Parkinson's Disease. PLoS One. 2015 Dec 2;10(12):e0143351. doi: 10.1371/journal.pone.0143351
- Ta NL, Seyfried TN. Influence of Serum and Hypoxia on Incorporation of [(14)C]-D-Glucose or [(14)C]-L-Glutamine into Lipids and Lactate in Murine Glioblastoma Cells. Lipids. 2015 Dec;50(12):1167-84.
- Seyfried TN. Cancer as a mitochondrial metabolic disease. Front Cell Dev Biol. 2015 Jul 7;3:43.
- Akgoc Z, Iosim S, Seyfried TN. Bis(monoacylglycero)phosphate as a Macrophage Enriched Phospholipid. Lipids. 2015 Sep;50(9):907-12.
- Poff AM, Ward N, Seyfried TN, Arnold P, D'Agostino DP. Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice: Novel Combination of Ketogenic Diet, Ketone Supplementation, and Hyperbaric Oxygen Therapy. PLoS One. 2015 Jun 10;10(6):e0127407.
- Maroon JC, Seyfried TN, Donohue JP, Bost J. The role of metabolic therapy in treating glioblastoma multiforme. Surg Neurol Int. 2015 Apr 16;6:61.
- Rockwell HE, McCurdy VJ, Eaton SC, Wilson DU, Johnson AK, Randle AN, Bradbury AM, Gray-Edwards HL, Baker HJ, Hudson JA, Cox NR, Sena-Esteves M, Seyfried TN, Martin DR. AAV-mediated gene delivery in a feline model of Sandhoff disease corrects lysosomal storage in the central nervous system. ASN Neuro. 2015 Apr 13;7(2).
- Meidenbauer JJ, Mukherjee P, Seyfried TN. nThe glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer. Nutr Metab (Lond). 2015 Mar
- Akgoc Z, Sena-Esteves M, Martin DR, Han X, d'Azzo A, Seyfried TN. Bis(monoacylglycero)phosphate: a secondary storage lipid in the gangliosidoses. J Lipid Res. 2015 May;56(5):1006-13.
- Heinecke KA, Luoma A, d'Azzo A, Kirschner DA, Seyfried TN.
- Myelin abnormalities in the optic and sciatic nerves in mice with GM1-gangliosidosis. ASN Neuro. 2015 Feb 18;7(1).
- McCurdy VJ, Rockwell HE, Arthur JR, Bradbury AM, Johnson AK, Randle AN, Brunson BL, Hwang M, Gray-Edwards HL, Morrison NE, Johnson JA, Baker HJ, Cox NR, Seyfried TN, Sena-Esteves M, Martin DR. Widespread correction of central nervous system disease after intracranial gene therapy in a feline model of Sandhoff disease. Gene Ther. 2015 Feb;22(2):181-9.
- Maroon JC, Seyfried TN, Donohue JP, Bost J. The role of metabolic therapy in treating glioblastoma multiforme. Surg Neurol Int. 2015 Apr 16;6:61.
- Rockwell HE, McCurdy VJ, Eaton SC, Wilson DU, Johnson AK, Randle AN, Bradbury AM, Gray-Edwards HL, Baker HJ, Hudson JA, Cox NR, Sena-Esteves M, Seyfried TN, Martin DR. AAV-mediated gene delivery in a feline model of Sandhoff disease corrects lysosomal storage in the central nervous system. ASN Neuro. 2015 Apr 13;7(2).
- Meidenbauer JJ, Mukherjee P, Seyfried TN. The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer. Nutr Metab (Lond). 2015 Mar 11;12:12.
- Akgoc Z, Sena-Esteves M, Martin DR, Han X, d'Azzo A, Seyfried TN. Bis(monoacylglycero)phosphate: a secondary storage lipid in the gangliosidoses.
- J Lipid Res. 2015 May;56(5):1006-13.
- Heinecke KA, Luoma A, d'Azzo A, Kirschner DA, Seyfried TN. Myelin abnormalities in the optic and sciatic nerves in mice with GM1-gangliosidosis. ASN Neuro. 2015 Feb 18;7(1).
- McCurdy VJ, Rockwell HE, Arthur JR, Bradbury AM, Johnson AK, Randle AN, Brunson BL, Hwang M, Gray-Edwards HL, Morrison NE, Johnson JA, Baker HJ, Cox NR, Seyfried TN, Sena-Esteves M, Martin DR. Widespread correction of central nervous system disease after intracranial gene therapy in a feline model of Sandhoff disease. Gene Ther. 2015 Feb;22(2):181-9.
- Seyfried TN, Flores R, Poff AM, D'Agostino DP, Mukherjee P. Metabolic therapy: a new paradigm for managing malignant brain cancer. Cancer Lett. 2015 Jan 28;356(2 Pt A):289-300.
- Mattson MP, Allison DB, Fontana L, Harvie M, Longo VD, Malaisse WJ, Mosley M, Notterpek L, Ravussin E, Scheer FA, Seyfried TN, Varady KA, Panda S. Meal frequency and timing in health and disease. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16647-53.
- Seyfried TN, Rockwell HE, Heinecke KA, Martin DR, Sena-Esteves M. Ganglioside storage diseases: on the road to management. Adv Neurobiol. 2014; 9:485-99.
- Seyfried TN. Ketone strong: emerging evidence for a therapeutic role of ketone bodies in neurological and neurodegenerative diseases.
- J Lipid Res. 2014 Sep; 55(9): 1815-7.
- Mantis JG, Meidenbauer JJ, Zimick NC, Centeno NA, Seyfried TN. Glucose reduces the anticonvulsant effects of the ketogenic diet in EL mice.
- Epilepsy Res. 2014 Sep; 108(7): 1137-44.
- Meidenbauer JJ, Ta N, Seyfried TN. Influence of a ketogenic diet, fish-oil, and calorie restriction on plasma metabolites and lipids in C57BL/6J mice.
- Nutr Metab (Lond). 2014 May 22; 11:23.
- Poff AM, Ari C, Arnold P, Seyfried TN, D'Agostino DP. Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer.n Int J Cancer. 2014 Oct 1;135(7):1711-20.
- Dufort FJ, Gumina MR, Ta NL, Tao Y, Heyse SA, Scott DA, Richardson AD, Seyfried TN, Chiles TC. Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation. J Biol Chem. 2014 Mar 7;289(10):7011-24.
- Seyfried TN, Flores RE, Poff AM, D'Agostino DP. Cancer as a metabolic disease: implications for novel therapeutics. Carcinogenesis. 2014 Mar;35(3):515-27.
- Ta NL, Jia X, Kiebish M, Seyfried TN. Autosomal dominant inheritance of brain cardiolipin fatty acid abnormality in VM/DK mice: association with hypoxic-induced cognitive insensitivity. Lipids. 2014 Jan;49(1):113-7.
- Ahmed SS, Li H, Cao C, Sikoglu EM, Denninger AR, Su Q, Eaton S, Liso Navarro AA, Xie J, Szucs S, Zhang H, Moore C, Kirschner DA, Seyfried TN, Flotte TR, Matalon R, Gao G. A single intravenous rAAV injection as late as P20 achieves efficacious and sustained CNS Gene therapy in Canavan mice.
- Mol Ther. 2013 Dec;21(12):2136-47.
- Poff AM, Ari C, Seyfried TN, D'Agostino DP. The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer.
- PLoS One. 2013 Jun 5;8(6):e65522.
- Bradbury AM, Cochran JN, McCurdy VJ, Johnson AK, Brunson BL, Gray-Edwards H, Leroy SG, Hwang M, Randle AN, Jackson LS, Morrison NE, Baek RC, Seyfried TN, Cheng SH, Cox NR, Baker HJ, Cachón-González MB, Cox TM, Sena-Esteves M, Martin DR. Therapeutic response in feline sandhoff disease despite immunity to intracranial gene therapy. Mol Ther. 2013 Jul;21(7):1306-15.
- Arthur JR, Wilson MW, Larsen SD, Rockwell HE, Shayman JA, Seyfried TN. Ethylenedioxy-PIP2 oxalate reduces ganglioside storage in juvenile Sandhoff disease mice. Neurochem Res. 2013 Apr;38(4):866-75.
Editorial Boards
- ASN NEURO, Senior Editor
- Journal of Lipid Research
- Neurochemical Research
- Nutrition & Metabolism
- Frontiers in Nutrition
- Frontiers in Oncology