Biology Department Faculty
Thomas Chiles
Professor and Deluca Chair of Biology
Vice Provost for Research & Academic Planning
Thomas Chiles
Ph.D.
Contact
Higgins Hall 544B
Telephone: 617-552-0840
Email: thomas.chiles@bc.edu
Education
- Ph.D., University of Florida
Department
Selected Publications
- Archibald, M.M., Rizal, B., Connolly, T., Burns, M.J., Naughton, M.J., Chiles, T.C. 2015. A nanocoaxial-based electrochemical sensor for the detection of cholera toxin. Biosens. Bioelectron. 74:406-410.
- Dufort FJ, Gumina MR, Ta NL, Tao Y, Heyse SA, et al. Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation. J Biol Chem. 2014 Mar 7;289(10):7011-24. PubMed PMID: 24469453; PubMed Central PMCID: PMC3945362.
- Rizal B, Archibald MM, Connolly T, Shepard S, Burns MJ, et al. Nanocoax-based electrochemical sensor. Anal Chem. 2013 Nov 5;85(21):10040-4. PubMed PMID: 24090275
- Blair D, Dufort FJ, Chiles TC, 2012. Protein kinase Cβ is critical for the metabolic switch to glycolysis following B-cell antigen receptor engagement. Biochem J. 448(1):165-9.
- Zhao H, Rizal B, McMahon G, Wang H, Dhakal P, Kirkpatrick T, Ren Z, Chiles TC, Naughton MJ, Cai D. 2012. Ultrasensitive chemical detection using a nanocoax sensor. ACS Nano. 6(4):3171-8.
- Jammallo L, Eidell K, Davis PH, Dufort FJ, Cronin C, Thirugnanam S, Chiles TC, Roos DS, Gubbels MJ. 2011. An insertional trap for conditional gene expression in Toxoplasma gondii: identification of TAF250 as an essential gene. Mol Biochem. Parasitol. 175(2):133-43.
- Crane, M.T. and Chiles, T.C. 2011. Why the Liberal Arts Need the Sciences (and Vice Versa). Commentary. The Chronicle of Higher Education. Nov. 13.
- Strelko, C.L., Lu, W., Dufort, F.J., Seyfried, T.N., Chiles, T.C., Rabinowitz, J.D., and Roberts, M.F. 2011. Itaconic acid, a polymer building block, is a novel mammalian metabolite induced during macrophage activation. J. Am. Chem. Soc. 133:16386-16389.
- Jammallo, L., Eidell, K., Davis, P.H., Dufort, F.J., Cronin, C., Thirugnanam, S., Chiles, T.C., Roos, D.S., and Gubbels, M.J. 2010. An insertional trap for conditional gene expression in Toxoplasma gondii: Identification of TAF250 as an essential gene. Mol. Biochem. Parasitol. 175:133-143.
- Gumina, M.R., Xu, C., Chiles, T.C. 2010. Cyclin D3 is dispensable for human diffuse large B-cell lymphoma survival and growth: Evidence for redundancy with cyclin E. Cell Cycle 9(4): 820–828. Epub 2010, Mar. 2.
- Yu, Y., Cimeno, A., Lan, Y.C., Rybczynski, J., Wang, D.Z., Paudel, T., Ren, Z.F., Wagner, D.J., Qiu, M.Q., Chiles, T.C., and Cai, D. 2009. Assembly of multi-functional nanocomponents on periodic nanotube array for biosensors. Micro & Nano Letters 4(1): 27–33.
- Cai, D., Blair, D., Dufort, F.J., Gumina, M.R., Huang, Z., Hong, G., Wagner, D., Canahan, D., Kempa, K., Ren, Z.F., and Chiles, T.C. 2008. Interaction between carbon nanotubes and mammalian cells: characterization by flow cytometry and application. Nanotechnology 19(34): 1–10.
- Wang, Y.K., Chen, W., Blair, D., Pu, M., Xu, Y., Miller, S.J., Redfield, A.G., Chiles, T.C., Roberts, M.F. 2008. Insights into the structural specificity of the cytotoxicity of 3-deoxyphosphatidylinositols. Journal of the American Chemical Society 130(24): 7746–7755. Epub 2008, May 23.
- Cai, D., Yu, Y., Lan, Y., Dufort, F.J., Xiong, G., Paudel, T., Ren, Z., Wagner, D.J., and Chiles, T.C. 2007. Glucose sensors made of novel carbon nanotube-gold nanoparticle composites. Biofactors 30(4): 271–277.
- Faber, A.C. and Chiles, T.C. 2007. Inhibition of cyclin-dependent kinase-2 induces apoptosis in human diffuse large B-cell lymphomas. Cell Cycle 6(23): 2982–2989.
- Dufort, F.J., Bleiman, B., Gumina, M.R., Blair, D., Wagner, D.J., Roberts, M.F., Abu-Amer, Y., and Chiles, T. C. 2007. Interleukin-4-mediated protection of primary B lymphocytes from apoptosis through Stat6-dependent up-regulation of glycolytic metabolism. Cutting Edge: Journal of Immunology 179: 4953–4957.
- Chiles, T.C., Mahon, K.P., Potocky, T.B., Blair, D., Roy, M. D., Stewart, K. M., and Kelley, S.O. 2007. Deconvolution of the cellular oxidative stress response with organelle-specific peptide conjugates. Chemistry & Biology 14(8): 923–930.
- Doughty, C. A., Bleiman, B. F., Wagner, D. J., Dufort, F. J., Mataraza, J. M., Roberts, M. F., and Chiles, T. C. 2006. Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth. Blood 107(11): 4458–4465.
- Cai, D., Mataraza, J. M., Qin, Z. H., Huang, Z., Huang, J., Chiles, T. C., Carnahan, D., Kempa, K., and Ren, Z. 2005. Highly efficient molecular delivery into mammalian cells using carbon nanotube spearing. Nature Methods 2(6): 449–454.