Publications
Dehn AS, Duhaime L, Gogan N, Nishina PM, Kelly, K, and Losick VP. Epithelial mechanics are maintained by inhibiting cell fusion with age in Drosophila. JCS. 2023 Sept. Accepted.
Dehn AS and Losick VP. Binucleation ramps up gene expression meeting the physiological demands of an organism. PLoS Biol. 2022 May 25;20(5):e3001639. doi: 10.1371/journal.pbio.3001639.
Dehn AS, Gogna N, Nishina PM, and Losick VP. Blocking cell fusion inhibits age-induced polyploidy and maintains epithelial organization in Drosophila. BioRxv. 2021, doi:https://doi.org/10.1101/2021.08.09.455651.
Losick VP and Duhaime L. The endocycle restores tissue tension in the Drosophila abdomen post wound repair. Cell Reports. 2021, Oct 12 (2):109827, doi:10.1016/j.cellrep.2021.109827.
Bailey EC, Kobielski S, Park J, and Losick VP. Polyploidy in Tissue Repair and Regeneration. Cold Spring Harbor Perspectives in Biology. 2021, Oct 1(10):a040881, doi: 10.1101/cshperspect.a040881.
Besen-McNally R, Gjelsvik KJ, and Losick VP. Wound-induced polyploidization is dependent on Integrin-Yki signaling. Biology Open. 2021, Jan 25. 10(1): bio055996.
Bailey EC, Dehn AS, Gjelsvik KJ, Besen-McNally R, and Losick VP. A Drosophila model to study wound-induced polyploidization. J Vis Exp. 2020, Jun 9;(160). doi: 10.3791/61252.
Grendler J, Lowgren S, Mills M, and Losick VP. Wound-induced polyploidization is driven by Myc and supports tissue repair in the presence of DNA damage. Development. 2019, Aug 2; pii: dev173005.
Gjelsvik KJ, Besen-McNally R, and Losick VP. Solving the polyploid mystery in health and disease. Trends in Genetics. 2019, Jan;35(1):6-14. Review.
Losick VP, Jun AS, and Spradling AC. Wound-Induced Polyploidization: Regulation by Hippo and JNK Signaling and Conservation in Mammals. PLoS One. 2016 Mar 9;11(3):e0151251.
Losick VP. Wound-induced polyploidy is required for tissue repair. Adv Wound Care. 2014, ahead of print. doi:10.1089/wound.2014.0545. Review.
Losick VP, Fox DT, and Spradling AC. Polyploidization and cell fusion contribute to wound healing in the adult Drosophila epithelium. Current Biology. 2013, Nov 18; 23(22):2224-32.
Losick VP, Morris LX, Fox DT, Spradling A. Drosophila stem cell niches: a decade of discovery suggest a unified view of stem cell regulation. Developmental Cell. 2011, Jul 19; 21(1):159-71. Review.
Liu M, Uehara T, Losick VP, Park JT, and Isberg RR. A Legionella pneumophila protein that facilitates evasion from Nod1 recognition. Cell Host Microbe. 2012, Aug 16; 12(2):166-76.
Losick VP, Haenssler E, Moy M, and Isberg RR. LnaB: a Legionella pneumophila activator of NF-kappaB. Cell Microbiology. 2010, Aug; 12(8):1083-97.
Li Z, Dugan AS, Bloomfield G, Skelton J, Ivens A, Losick VP, and Isberg RR. The amoebal MAP kinase response to Legionella pneumophila is regulated by DupA. Cell Host Microbe. 2009, Sep 17; 6(3):253-67.
Losick VP*, Stephan KS*, Isberg, RR, Poltorak A. A hemidominant Naip5 allele in MOLF/Ei-derived macrophages restricts L. pneumophila intracellular growth. Infection and Immunity. 2009, Jan; 77(1):196-204. *Co-primary authors.
Losick VP and Isberg RR. NF-appaB translocation prevents host cell death after low-
dose challenge by Legionella pneumophila. Journal of Experimental Medicine. 2006,
Sep 4; 203(9):2177-89.
Losick VP, Schlax PE, Emmons RA, Lawson TG. Signals in Hepatitis A Virus P3 region
Proteins recognized by the ubiquitin-mediated proteolytic system. Virology. 2003, May 10; 309(2):306-19.