Complex Problems Require Ternary Solutions: Another Lesson from SIV Nef

September 11, 2019
Welkin E. Johnson and Kevin R. McCarthy
Cell Host & Microbe

Abstract
In this issue of Cell Host & Microbe, Buffalo et al. describe a cryo-EM structure of SIV Nef complexed with AP-2 and tetherin. The structure helps explain why human tetherin is Nef-resistant and why lentiviruses that successfully emerged in humans (HIV-1 and HIV-2) had to evolve novel anti-tetherin strategies. Read more