Professor Peter Clote's First Volume of "RNA: Computational Methods for Structure, Kinetics, and Rational Design" is Now Available

Comprising two volumes, Biology Professor Peter Clote's RNA: Computational Methods for Structure, Kinetics, and Rational Design is a comprehensive treatment of computational methods concerning the secondary structure, folding kinetics and rational design of RNA.

RNA computational biology is an interdisciplinary research field, involving contributions from physical chemistry (determination of free energy parameters), polymer physics (calculation of entropy by Gaussian integrals and enumeration of self-avoiding walks), mathematics (combinatorics that leads to dynamic programming algorithms) and computer science (efficient algorithm design and implementation). Volume 1 of this new ~400 page monograph describes how energy parameters are determined, and how effficient structure prediction algorithms are designed that use such parameters. These algorithms have ubiquitous applications in molecular biology, ranging from prediction of microRNA targets in messenger RNA to the design of RNA thermoswitches, a topic in synthetic biology. The forthcoming Volume 2 describes folding kinetics and the rational design of RNA molecules. The focus of the monograph is not on tool use, but rather tool design: figuratively, the reader is given a chisel, hammer, design plans of the Notre Dame and provided the wherewithal to reconstruct the cathedral.

This publication is available for pre-order on October 30, 2024. Item will ship after November 20, 2024